Strengthened luteal phase support for patients with low serum progesterone on the day of frozen embryo transfer in artificial endometrial preparation cycles: a large-sample retrospective trial
نویسندگان
چکیده
Abstract Background Low serum progesterone on the day of frozen embryo transfer (FET) is associated with diminished pregnancy rates in artificial endometrium preparation cycles, but there no consensus whether strengthened luteal phase support (LPS) benefits patients low FET cycles. This single-centre, large-sample retrospective trial was designed to investigate contribution LPS outcomes for groups levels Methods Women who had undergone first cycle after a freeze-all protocol our clinic from 2016 2018 were classified into two depending their day. Routine administered group B ( P ≥ 10.0 ng/ml day, n = 1261), and (routine LPS+ im 40 mg daily) A < 1295). The primary endpoint live birth rate, secondary endpoints clinical pregnancy, miscarriage neonatal outcomes. Results results showed that rate significantly lower than (48.4% vs 53.2%, adjusted risk ratio (aRR) 0.81, 95% confidence interval (CI) 0.68, 0.96), whereas similar between (16.0% 14.7%, aRR 1.09, CI 0.77, 1.54). slightly (39.5% 43.3%, 0.84, 0.70, 1.0). Birthweights other > 0.05). Conclusions indicated level one factors predicting chances might help provide reasonable outcome although further prospective evidence needed confirm this possibility.
منابع مشابه
Effect of Progesterone Supplementation on Natural Frozen-Thawed Embryo Transfer Cycles: A Randomized Controlled Trial
متن کامل
The effect of luteal phase progesterone supplementation on natural frozen-thawed embryo transfer cycles
OBJECTIVE To evaluate the effect of progesterone supplementation during the luteal phase on pregnancy outcome in natural frozen-thawed embyo transfer (FTET) cycles. METHODS In this retrospective cohort study, 228 consecutive patients who underwent FTET cycles between January 2009 and September 2012 were included. One hundred forty-five patients received luteal progesterone support (P group) b...
متن کاملEffect of Adding Human Chorionic Gonadotropin to The Endometrial Preparation Protocol in Frozen Embryo Transfer Cycles
متن کامل
Methods for endometrial preparation in frozen-thawed embryo transfer cycles.
Frozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization- intracytoplasmic sperm injection cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. However, the best solution for endo...
متن کاملI-29: Luteal Phase Support in Frozen-Thawed Embryo Transfer Cycle
Cumulative pregnancy rate has been significantly increased since frozen-thawed embryo transfer was applied in ART cycles. This method has become an essential part of IVF/ICSI treatment. Luteal phase support has been proven to be associated with higher rate of live birth rate. Human chorionic gonadotropin (HCG), and progestrone have been successfully used for luteal phase support in ovarian stim...
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ژورنال
عنوان ژورنال: Reproductive Biology and Endocrinology
سال: 2021
ISSN: ['1477-7827']
DOI: https://doi.org/10.1186/s12958-021-00747-8